Source: mikeash
I was troubleshooting with a user of an audio streaming application running over a LAN. The user could stream classical music but not rock music. Seriously. Classical was fine, but when streaming rock, the connection would drop after a few minutes.
The application took chunks of audio, compressed them with a lossless codec, and then sent each chunk in a separate UDP packet to the other end. It tried to use IPv6 whenever possible because it was generally more reliable in the LAN environment, although it would happily use IPv4 if need be.
After a huge amount of boring troubleshooting going back and forth with this guy, I finally figured it out. Somehow, he had set his network interface's MTU to 1200 bytes. IPv6 won't perform automatic IP-level fragmentation for MTUs below 1280 bytes, so larger packets simply could not be sent at all. The streaming application would try to send an audio packet larger than 1200 bytes, get an error, and bail out of the connection.
Why did it only happen with rock music? Turns out to be pretty simple. Lossless codecs are necessarily variable bitrate, and classical music compresses better than rock music. When streaming classical, each chunk of audio consistently compressed to less than 1200 bytes, but rock music produced occasional packets over the threshold.
The user didn't know why his MTU was turned down and didn't need it, so we turned it back up and everything worked just fine.